Modern life poses many threats to good-quality sleep, challenging brain health across the lifespan. Disrupted sleep, especially during adolescence, can contribute to alter brain connectivity and impair the functionality of brain regions underlying high cognitive functions, resulting in aberrant behavior. Our preliminary data suggest that adolescent chronic sleep restriction may induce significant morphological and functional changes in brain regions relevant for reward and affective status, through mechanisms involving synapse-glia interactions. The research goal of this project is to understand the consequences of adolescent chronic sleep restriction and its contribution to maladaptive neurodevelopmental changes leading to enhanced vulnerability to substance use disorders.

CAREER DEVELOPMENT AWARD, per giovani ricercatori italiani all’estero
Armenise-Harvard Foundation
€ 600.000,00
€ 600.000,00