Osteosarcoma (OS) is a primary malignant bone tumor with a high propensity for metastasis, particularly in adolescents and young adults. Despite advances in cancer therapy, the current standard of care for OS has remained largely unchanged since the 1980s, resulting in suboptimal survival rates, particularly for patients with metastatic disease.

The MARMADE project aims to develop sustainable, high-value food and feed ingredients from marine biomass, focusing on crustacean residues (shrimp shells and blue crabs) and seaweed.

This proposal will test the efficacy of the GABAB receptor agonist, R-Baclofen, on compulsive alcohol consumption, considering sex as a biological factor in an animal model of interindividual heterogeneity.

Development of pharmacological agents for the treatment of alcoholism targeting the CRF-binding protein

The objective of the project is the clinical development of Cebranopadol for the treatment of opioid addiction. The project may be funded by the NIH-NIDA, and the study will be conducted in collaboration with Park Therapeutics, the company that holds the property rights to the molecule.

Aim of the project is to evaluate the therapeutic potential of a new synthetic molecule, called BU10119, for the treatment of alcohol addiction. This molecule acts as a NOP agonist and MOP antagonist.

Neuroinflammation plays a pivotal role in the pathogenesis of neurodegeneration in Parkinson's Disease (PD) through the upregulation of proinflammatory factors and microglia activation. The purinergic P2X7 receptor (P2X7R) is among the targets actively investigated as PET biomarkers of neuroinflammation because of its crucial role in microglia activation and expression associated with