This proposal will test the efficacy of the GABAB receptor agonist, R-Baclofen, on compulsive alcohol consumption, considering sex as a biological factor in an animal model of interindividual heterogeneity.
The objective of the project is the clinical development of Cebranopadol for the treatment of opioid addiction. The project may be funded by the NIH-NIDA, and the study will be conducted in collaboration with Park Therapeutics, the company that holds the property rights to the molecule.
Aim of the project is to evaluate the therapeutic potential of a new synthetic molecule, called BU10119, for the treatment of alcohol addiction. This molecule acts as a NOP agonist and MOP antagonist.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegeneration in Parkinson's Disease (PD) through the upregulation of proinflammatory factors and microglia activation. The purinergic P2X7 receptor (P2X7R) is among the targets actively investigated as PET biomarkers of neuroinflammation because of its crucial role in microglia activation and expression associated with
Questo progetto riguarda lo studio del ruolo dell´amigdala centrale ed il gene PKCD nell´uso compulsivo dell´eroina. Per la realizzazione di questo progetto lè stata importata dalla Svezia una linea di ratti transgenici "Prkcd Cre Knock in" presso lo stabulario della Scuola del Farmaco, dove il gene PKCD verra´ manipolato attraverso degli approcci virali per testarne il suo ruolo in un modello preclinico di consumo compulsivo di eroina.
During this RISE project we aim to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part
