Mosquito-borne diseases (MBDs) affect mostly tropical countries, but globalization and climate changes are increasing the risk of transmission in Europe, where the native Culex pipiens (vector of endemic West-Nile virus) is widespread and invasive species (i.e. Aedes vectors of exotic arboviruses such as Dengue) are increasing. Moreover, high mosquito densities represent a major nuisance affecting people's wellbeing.

Modulating synaptic neurotransmission to reactivate the immune reaction against brain tumors

Glioblastoma (GB) is an aggressive and immunosuppressed brain tumor with few therapeutic options. The development of novel therapies requires a better understanding of the bi-directional communication between the tumor and the surrounding brain parenchyma. On one hand, soluble factors released by GB cells alter the balance of inhibitory and excitatory neurotransmission, and disrupt neural circuits; on the other, recent findings suggest that neuronal stimuli modulate brain microenvironment with effects on tumor growth.

Dynamics and timescales of volcanic plumbing systems: a multidisciplinary approach to a multifaceted problem

Crystals in volcanic rocks preserve information about the processes that occurred in the plumbing system and during the transfer of magma to the Earth’s surface and are fundamental messengers carrying key information on the timescales of eruptive processes. In the last years, we have seen an extraordinary advancement in the development of new and progressively more sophisticated analytical and experimental equipment.

Combined targeting of TSPO/CK1delta/GSK3beta/Fyn for effective control of neuroinflammation: a chemical biology approach

Evidence exists that neuroinflammation plays a crucial role in the development and progession of many chronic neurologic diseases, Alzheimer's (AD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and Parkinson's (PD). Although microglial cells are generally considered as the main resident immune cells of the brain, it is important to underline that astrocytes are immunocompetent as well, and they act as important regulators of CNS inflammation.

Study and optimization of cold atmospheric plasma treatment for food safety and quality improvement

The main objective of this project is to provide a deeper knowledge about aspects still scarcely investigated about cold atmospheric plasma (CAP) treatment of food products to fill the gaps identified in the literature, promoting the application of this emerging novel technology. Five different categories of food products (minimally process fruit and vegetables -MPFV, semidried fruit -SDF, dry fruit -DF, fish products -FP and molluscs -M) were chosen on the basis of their different characteristics and issues related to safety and stability.

Mathematical Logic: models, sets, computability

Contemporary research in mathematical logic shows increasing interactions between Model Theory (MT), Set Theory (ST), and Computability Theory (CT), guided by inner developments which progressively found applications to larger and larger areas of mathematics. Problems originating from MT lead naturally to ST and CT questions, while the forcing method, originally developed within ST, and the tecniques of descriptive set theory find applications in MT and CT. Our project is inserted in this general setting.

Engineering coherent transport of atoms and electrons in layered structures

The central goal of this project is to identify the mechanisms behind decoherence of quasiparticle transport in layered materials and to devise successful strategies for preserving and harnessing quantum many-body correlations in real devices. We will establish a collaborative effort involving two of the most prominent platforms for quantum transport: ultracold quantum gases in optical lattices and transition-metal oxide heterostructures.