Reactions in volatile organic solvents (VOCs) have served as important methods for carbon-carbon bond formation. The release of VOCs into the environment, however, still remains a matter of great concern, and a number of regulations are currently in place to control their use. NATUREChem Consortium will pursue the development of an innovative and greener technology based on the use of unconventional, environmentally friendly, clean, nature-mimicking media (the so-called Deep Eutectic Solvents, DESs) for a profound advance of knowledge and for a sustainable development of (a) organo, bio-, and metal-catalysed processes, (b) organic transformations mediated by highly polar organometallics, (c) bio-based protocols, in batch and in flow, for the preparation of targeted heterocycles of pharmaceutical relevance, and (d) the next-generation of solar technologies for the dye-sensitized generation of electricity and fuels from sunlight and clean, abundant, and renewable sources. This would immensely lower production costs, save life-supporting natural resources such as energy, minimise chemical hazards, improve existing and create new applications in fine chemicals, advanced organic material industries, and solar devices for next generation energy issues.