The aging process is associated with a decline in the function of our senses (Age Related Sensory Decline or ARSD). Sensory deficits may explain why elderly people report poorer quality of life and challenges in interacting with the environment and other people. Little is known regarding genetics and environmental/lifestyle risk factors for ARSD. In this light, we will address the biology of ARSD with a convergent methodology that integrates large population and centenarians data (environmental, lifestyle, deep phenotypes, etc.), with “omics” data and functional in vitro and in vivo studies in a very innovative unbiased approach never applied before for the study of ARSD. Thanks to this project we plan to increase our knowledge on: a) the impact of ARSD in the daily lifestyle of the elderly, b) the role of environmental factors (i.e. lifestyle, medications, etc.), c) the genetic risk factors and pathways and how they can predict individual ARSD, d) the interactions between ARSD genetic variants, individual molecular phenotype and sensory deficits, and those between aging mechanism and genetic determinants. SENSAGING will not only lay the foundation for a thorough understanding of ARSD but also provide tools for its prevention, early diagnosis, and clinical management.